Conference Proceedings

Конференція: Фундаментальні науки – практичній медицині: морфо-функціональні методи дослідження онтогенетичних перетворень, фізіологічних та метаболічних процесів, змодельованих патологічних станів, при захворюваннях внутрішніх органів

Напрямок: Морфологічні аспекти в клінічній практиці.

Reviving matrix (anti-gliotic guiding regenerative gel) for reconstruction of severely injured peripheral nerve and spinal cord

Authors

  • Rochkind Shimon Research Center for Nerve Reconstruction, Tel Aviv Sourasky Medical Center,Tel Aviv University, Israel
  • Almog Mara Research Center for Nerve Reconstruction, Tel Aviv Sourasky Medical Center, Israel
📧Corresponding author

Abstract

Peripheral nerve injury (PNI) leads to partial or complete paralysis, severe pain, disabilities and deterioration in quality of life. PNI occurs in about 2.8% of all trauma patients. Incidence of nerve injuries is 13.9/100,000 inhabitants per year. The innovative Anti-gliotic Guiding Regenerative Gel (AGRG) is a special milieu that increases nerve growth and promotes recovery, aiming, ultimately, at restoring the function of an injured peripheral nerve and enable spinal cord repair. The AGRG is composed of: 1) anti-oxidant, found to protect cells from oxidative stress, regulating immune function, maintaining endothelial cell integrity; 2) proprietary peptide (16 amino acids) based on the active sites of laminin peptide and containing two penta-peptides, which acts as a scaffold for the nerve fibers to grow along; 3) hyaluronic acid, which is highly hydrated and contributes to the success of survival, growth and regeneration of nerve fibers by protecting them from drying; and 4) copaxone is an immunomodulatory and neuroprotective drug. These results show that treatment with AGRG was active in enhancing spinal repair in both acute and chronic SCI models in rats; highlighting that AGRG\'s superiority in promoting neuronal regeneration. AGRG opens a new modality in treatment of injured nerves, enabling the introduction of composite implant, with decreased time and improved quality of recovery, for clinical applications.

Keywords

AGRG nerve rat spinal cord injury

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References

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